Anti-aging Mitochondrial Peptides Under research

MOTS-c

Also known as: Mitochondrial Open Reading Frame of the 12S rRNA-c

MOTS-c is a 16-amino acid mitochondria-derived peptide (MDP). It is encoded directly by mitochondrial DNA, not by nuclear DNA. It is known as an "exercise-mimetic" peptide because it regulates metabolism and protects against diet-induced obesity by acting directly on skeletal muscle tissue to increase glucose uptake.

Mechanism of action

Primarily targets skeletal muscle tissue, increasing glucose utilization independent of insulin (AMPK-dependent pathway).
Stimulates AMPK (AMP-activated protein kinase), the body's main energy-sensing enzyme, naturally activated by prolonged cardiovascular exercise.
Increases mitochondrial biogenesis (creation of new mitochondria) in cells.

Uses & indications

Athletic performance: Improvement of aerobic capacity and fatigue resistance.
Insulin resistance: Drastically increases cellular sensitivity.
Anti-aging: Metabolic intervention to counter age-related energetic decline.

Effects

Noticeable increase in energy, higher cardiovascular endurance, facilitated fat loss, optimized blood sugar levels.

Considerations & contraindications

Very short half-life, requires injection right before physical activity or daily.
Can cause a slight drop in glucose if used during a deep fast.

Regulatory approval

Used in cutting-edge longevity research.

Dosage

Common research protocols use 5mg to 10mg injected 2 to 3 times per week before training.

Storage

Lyophilized at -20°C. Reconstituted keep refrigerated (fragile).

Technical data

Regulatory status Under research

Molecular weight 2174.6 Da

Half-life Escasos minutos en plasma (efectos de transcripción prolongados)

Administration routes Subcutánea