Anti-aging Neuropeptides Mitochondrial Peptides Under research

Epithalon

Also known as: Epitalon, Epithalone, Ala-Glu-Asp-Gly

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) designed from epithalamin, a substance produced by the pineal gland. Primarily investigated in longevity research for its ability to activate telomerase, elongate telomeres, and regulate circadian rhythm. Developed by the St. Petersburg Institute of Gerontology (Russia).

Mechanism of action

Telomerase activation: Stimulates telomerase enzyme in somatic cells, extending telomeres and delaying cellular senescence
Melatonin regulation: Normalizes melatonin production by the pineal gland
Antioxidant properties: Reduces oxidative stress and lipoperoxidation product levels
Neuroendocrine modulation: Regulates the hypothalamic-pituitary-gonadal axis

Uses & indications

Anti-aging: Potential extension of healthy lifespan
Sleep improvement and circadian rhythm regulation
Retinal protection: Studies in macular degeneration
Experimental oncology: Antiproliferative effects in tumor cell lines (in vitro)

Effects

Animal evidence: Studies in rodents at the St. Petersburg Gerontological Institute showed 24–33% median lifespan extension and reduced spontaneous tumor incidence.

Adverse effects: Minimal reported. Some anecdotal reports of vivid dreams, mild headache. No evidence of toxicity at standard doses.

Considerations & contraindications

Not approved by FDA/EMA; no large-scale human clinical trials
Telomerase activation could theoretically favor tumor cells (hypothetical risk)
Long-term effects in humans unknown
Do not use during pregnancy

Regulatory approval

Research peptide. Approved in Russia for limited geriatric use. Not approved in Western countries. Investigated by Vladimir Khavinson (Institute of Gerontology, St. Petersburg).

Dosage

Typical protocols: 5–10 mg/day for 10–20 days (cycle). Repeat 2–4 times/year.

Storage

Lyophilized: −20°C. Reconstituted: 4°C, use within 2–3 weeks.

Technical data

Regulatory status Under research

Molecular weight 390.35 Da

Half-life Corta (minutos–horas)

Administration routes Subcutánea, intramuscular, sublingual