Mitochondrial Peptides Under research

SS-31

Also known as: Elamipretide, Bendavia, MTP-131

SS-31 (Elamipretide) is a small synthetic tetrapeptide that penetrates the inner mitochondrial membrane, where it acts by restoring cellular function and neutralizing reactive oxygen species (ROS). It is a revolutionary direct mitochondrial antioxidant. It reverses mitochondrial damage caused by aging, ischemia, and various degenerative diseases.

Mechanism of action

Selectively binds to cardiolipin on the inner mitochondrial membrane.
Stabilizes cardiolipin, restoring mitochondrial structure and the electron transport chain.
Prevents electron leakage and massively reduces free radical production at the source without interfering with normal cellular respiration.

Uses & indications

Profound anti-aging: Restoration of cellular vitality in high-consumption organs (heart, brain, kidneys).
Neurodegeneration: Investigated in Alzheimer's and Parkinson's models.
Heart failure and ischemic damage: Protects against reperfusion injury following a heart attack.

Effects

Systemic rejuvenation of organ function, greater tolerance to oxidative stress, prevention of age-associated cognitive and organic decline.

Considerations & contraindications

Extremely high cost of synthesis and acquisition in pharmaceutical purity.
Very safe, with no severe adverse events in studies.

Regulatory approval

In advanced clinical trials by Stealth BioTherapeutics.

Dosage

In aging studies, research doses are typically around 4mg daily administered subcutaneously.

Storage

Lyophilized at -20°C.

Technical data

Regulatory status Under research

Molecular weight 639.8 Da

Half-life Aproximadamente 2 horas

Administration routes Subcutánea o Intravenosa