Immune Modulators Under research

KPV

Also known as: Lys-Pro-Val

KPV (Lysine-Proline-Valine) is a tripeptide (three-amino acid peptide) found at the C-terminal portion of alpha-melanocyte-stimulating hormone (alpha-MSH). It is a potent antimicrobial and anti-inflammatory agent. Being so small, it can easily penetrate cells and is well-absorbed topically, orally, or subcutaneously.

Mechanism of action

Inhibits the NF-kB inflammatory pathway intracellularly, reducing the production of pro-inflammatory cytokines.
Displays strong antimicrobial properties against certain bacteria (like S. aureus) and fungi (like Malassezia and Candida).
Alleviates inflammation without the immunosuppressive side effects associated with steroids or other anti-inflammatories.

Uses & indications

Inflammatory Bowel Disease (IBD): Highly effective in ulcerative colitis and Crohn's (especially in oral formulations).
Dermatology: Psoriasis, atopic dermatitis, acne, and wound healing (topical formulations).
Allergies and asthma: To reduce hyperreactivity and inflammation.

Effects

Rapid resolution of localized and systemic inflammation, accelerated healing of skin or intestinal mucosa wounds, mitigation of autoimmune symptoms.

Considerations & contraindications

Can be administered in creams, sprays, capsules, or injections, making it very versatile.
Extremely well-tolerated and safe.

Regulatory approval

Currently under investigation for various indications, particularly in IBD and dermatology.

Dosage

Typical injections of 200-500mcg daily. In oral use (capsules for gut) often 500mcg - 1mg daily.

Storage

Stable at room temperature in dry form. Reconstituted keep refrigerated.

Technical data

Regulatory status Under research

Molecular weight 383.5 Da

Half-life Corta en plasma, pero efectos intracelulares duraderos

Administration routes Subcutánea, Oral, Tópica, Spray

KPV